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KMID : 0361020220650050268
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Korean Journal of Otolaryngology - Head and Neck Surgery
2022 Volume.65 No. 5 p.268 ~ p.275
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Clinical Characteristics and Treatment Outcome of Squamous Cell Carcinoma Associated With Inverted Papilloma: Comparison With Sinonasal de Novo Squamous Cell Carcinoma
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Park Soo-Kyoung
Kang Jae-Yoon
Kim Yong-Min
Rha Ki-Sang
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Abstract
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Background and Objectives : Squamous cell carcinoma associated with inverted papilloma (IP+SCC) is different histologically and biologically from sinonasal de novo squamous cell carcinoma (dnSCC). However, few studies have compared the characteristics of patients, be- haviors of tumor, and treatment outcome of two different forms of SCC.
Subjects and Method : We retrospectively reviewed the medical records of 30 patients with
IP+SCC and 39 patients with dnSCC who had been treated at Chungnam National University
Hospital from 1989 to 2018. Demographics, clinicopathological characteristics, treatment modalities and outcome were analyzed.
Results : The mean age, sex ratio, and the proportion of smokers were similar in both groups. On the other hand, the presenting symptoms of each group were somewhat different: nasal symptoms were more frequent in the IP+SCC group, whereas facial symptoms were more frequent in the dnSCC group. Patients with dnSCC showed significantly more advanced T stage, poorer differentiation of cancer cells, and more bone destruction. The upfront method of treatment was surgery in both groups, whereas radiotherapy and chemotherapy were more frequently used as an adjuvant or main treatment in the dnSCC group. Patients with IP+SCC demonstrated better 5-year overall survival and disease-free survival than the dnSCC group In both groups, patients with the lower T stage had better outcome than those with the higher
T stage. The presence of nodal or distant metastasis was an independent, poor prognostic factor for survival regardless of the type of tumor
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Conclusion : Although sinonasal IP+SCC and dnSCC are often considered similar diseases, our findings suggest that IP+SCC may represent a less aggressive form of malignancy than dnSCC.
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KEYWORD
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Inverted, Nasal cavity, Papilloma, inverted, Paranasal sinuses, Squamous cell carcinoma
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